Van de Ven Double Ends Everton's Unbeaten Streak at Brand New Stadium
The Dutch defender became the first backline player to score twice in a English top-flight game for Spurs since the Belgian defender in March 2013.
At a glance
The Spurs defender heads home twice in opening period
The home side's Jake O'Brien has goal disallowed after video check
Senegalese midfielder nets final goal in dying moments
The defeat is the Merseyside club's first at Hill Dickinson Stadium
The Tottenham defender scored twice as Tottenham extended their winning streak in away games in the top division and delivered the Toffees their first defeat at their new home.
The Toffees were undefeated in their last five matches at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after more than a century at the conclusion of last season.
But Tottenham's leader the Dutchman pounced on two occasions from set-pieces in the opening 45 minutes to put their strong form at risk, and they were unable to mount a comeback before the midfielder - assisted by former Toffees attacker the Brazilian - nodded in a third to seal the victory.
The Everton defender believed he had equalized the tally a short while after the defender's first goal, glancing a powerful header past the Spurs keeper from an set-piece.
The Portuguese striker, in the meantime, failed to convert a handful of opportunities, while the Italian goalkeeper made a series of excellent stops to ensure Tottenham went five matches on the road without defeat in the English top flight.
But the VAR stepped in, advising the match official to check the score on the screen and the official ruled that the winger and the attacker were in offside positions and had impeded with the Tottenham goalkeeper.
The win moves the manager's side into third place in the Premier League, a handful of points off local foes and leaders Arsenal.
The Merseyside club stay 14th and sit six points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils duties at both ends of pitch
Following a uninspiring midweek performance in the Champions League against the French side, where they mustered a mere two shots on goal, the manager chose the French striker up front instead of former Toffees player the Brazilian.
The new arrival was unable to influence the game before being substituted for the substitute after an hour on the field, but it turns out he proved unnecessary in the end.
Defender the Dutchman transformed into an offensive threat to be reckoned with.
Tottenham's opening strike came from a well-worked set-piece play, with the midfielder directing the ball back across the face of goal for an free the defender to head home.
And the captain - stepping up as captain in Cristian Romero's unavailability - notched his second in added time as he rose above the England keeper to nod in.
Van de Ven was just as impressive in defence, partnering effectively with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by the opposition.
Toffees breakdown: Everton missing striker's instinct
Everton's new home had been a fortress, but it seems the novelty may have worn off somewhat and fans headed to the gates after Sarr's third for Tottenham.
The end in the team's winning streak at home will not be a major worry for the manager, but their attacking woes will be.
Beto and Thierno Barry - the Toffees' pair of established centre-forwards - had netted just a single goal combined before Sunday's outing.
And they were unable to contribute to that miserable record on a damp and dreary evening on Merseyside.
The striker's form was summed up when he opted to overhead kick a clear chance from close range, even with having room and time to reposition for a simpler attempt that would have tested the keeper.
Barry, as well, was unable to make an impact after replacing Beto in the 65th minute.
It wasn't for a lack of chance. The majority of Everton's attacks came through the winger and the forward, who tirelessly delivered dangerous crosses into the Spurs penalty area.
Upcoming fixtures for these two sides?
The Toffees: The team travel to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: The London club go to Newcastle's ground on Wednesday, 29 October for their fourth-round Carabao Cup match against Newcastle.